| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | The R219K SNP was examined in 256 centenarians and 190 healthy younger controls. The allelic frequency were not different between the two groups [12601526]. | Human |
| MIR145 | microRNA 145 | MIR145 is a tumor suppressor that acts by inhibiting IRS-1 in human colon cancer cells. It also targets IGFR1 [17827156; 19391107]. It decreases cell migration in gliomas by targeting CTGF, metastasis and migration-promoting gene. MIR145 is downregulated in astrocytic tumors and oligodendrogliomas [23390502;
23577178]. | Human |
| MIR16-1 | microRNA16-1 | MIR16-1 is a tumor-suppressor downregulated in different types of cancers. In chronic lymphocytic leukemia (CLL) it is downregulated in 68% of cases [12434020]. MIR16-1 may post-transcriptionally downregulate the expression of Bcl2, thus inducing apoptosis. Therefore, inactivation of MIR15A and MIR16-1 in CLL lymphocytes results in a reduced apoptosis rate [16166262].
In prostate cancer, MIR15A and MIR16-1 are downregulated, which results in decreased repression of FGF-2, thus promoting tumor expansion and invasiveness [21532615].
MIR15A and MIR16-1 are also downregulated in pituitary adenomas as thier expression exhibits an inverse correlation with tumor diameter, therefore possible influence on tumor growth [15648093]. | Human |
| MIR15A | microRNA 15a | MIR15A is a tumor-suppressor downregulated in different types of cancers. In chronic lymphocytic leukemia (CLL) it is downregulated in 68% of cases [12434020]. MIR15A may post-transcriptionally downregulate the expression of Bcl2, thus inducing apoptosis. Therefore, inactivation of MIR15A and MIR16-1 in CLL lymphocytes results in a reduced apoptosis rate [16166262].
In prostate cancer, MIR15A and MIR16-1 are downregulated, which results in decreased repression of FGF-2, thus promoting tumor expansion and invasiveness [21532615].
MIR15A and MIR16-1 are also downregulated in pituitary adenomas as thier expression exhibits an inverse correlation with tumor diameter, therefore possible influence on tumor growth [15648093]. | Human |
| TSA | Trichostatin A | Histone deacetylase inhibitor Trichostatin A (TSA) extends the lifespan of *Drosophila melanogaster* by promoting the hsp22 gene transcription, and affecting the chromatin morphology at the locus of hsp22 gene along the polytene chromosome [15346199].
hsp70 and hsp22 RNA levels are higher in long-lived than in short-lived fly lines. The HDAC inhibitor TSA causes a higher expression of hsp22 and hsp70, and strikingly influences the lifespan in both long and short-lived lines, with variable degrees (up to 25%) [15695762].
| Human |
| MIR106A | microRNA 106A | MIR106A is downregulated in senescent cells as it has a good correlation with p21 transcription, while p53 represses mir17-92 cluster [20437201; 20089119]. | Human |
| miR17 | microRNA 17 | miR17 is downregulated in senescent cells and has a good correlation with p21 transcription, while p53 represses mir17-92 cluster [20437201; 20089119] | Human |
| miR222 | microRNA 222 | miR221 and miR222 downregulate PTEN, a major tumor suppressor and TIMP3, which induces activation of caspases 8 and 9 [19962668]. Thus miR221 and miR222 enhance tumorigenecity in cell lung cancer, gastric cancer and hepatocarcinoma cells [20618998]. | Human |
| miR221 | microRNA 221 | miR221 and miR222 downregulate PTEN, a major tumor suppressor and TIMP3, which induces activation of caspases 8 and 9 [19962668]. Thus miR221 and miR222 enhance tumorigenecity in cell lung cancer, gastric cancer and hepatocarcinoma cells [20618998] | Human |
| MIR29A | microRNA 29a | miR-29a reduces the amount of methylation and upregulates a long non-coding RNA form a region called MEG3 that is responsible for inducing apoptotic pathway. Thus reducing tumorgensis in non-malignant hepatocytes [21625215].
| Human |
| EXO1 | exonuclease 1 | The rs1776180 C allele in the promoter of EXO1 is significantly enriched in female Germans centenarians and this can be replicated in 445 female French centenarians. The C allele leads to the loss of binding site for the basic helix-loop-helix transcription factor E47, resulting in higher EXO1 expression [19698732]. | Human |
| THC | Tetrahydocurcumin | Tetrahydocurcumin extends the lifespan and reduces oxidative stress in male and female fruit flies. THC extends lifespan of Drosophila and inhibits the oxidative stress response by regulating *FOXO* and *Sir2* [22156377].
In male mice supplementation with tetrahydrocurcumin beginning at the age of 13 month increases the mean lifespan by an average of 84 days, i.e. an increase of 11.7% [17516143].
| Human |
| DRD4 | Dopamine D4 Receptor | DRD4 7R allele frequency is correlated with longevity. DRD4 moderates the impact of environments on behaviour and health. The oldest population have a 66% increase in individuals carrying the DRD4 7R allele relative to the younger ones and this genotype is strongly correlated with increased levels of physical activity [23283341]. | Human |
| CCL2 | chemokine (C-C motif) ligand 2 | CCL2 levels in plasma increase with age and it is part of the senescence-associated secretory phenotype [19648977]. | Human |
| CCL11 | chemokine (C-C motif) ligand 11 | CCL11 exhibits an age-related increase in the plasma and cerebrospinal fluid from healthy human individuals between 20 and 90 years [21886162]. | Human |
| BUB1B | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | Mutations in BUB1B are associated with mosaic variegated aneuplody, a rare human syndrome characterized by aneuplodization, tumour predisposition and several progeroid traits, including short lifespan, growth and mental retardation, cataracts and facial dysmorphisms [16411201; 15475955; 20651707]. | Human |
| MIR21 | MIRN21; hsa-mir-21; miR-21; miRNA21 | MIR21 is the most highly expressed microRNA gene in octogenarians and centenarians. MIR21 expression is higher under cardiovascular diseases and lower in centenarian offspring. MIR21 is correlated with C-reactive protein and fibrinogen levels. TGF-βR2 mRNA, a MIR21 target, exhibits the highest expression in leukocytes form a subset of octogenarians. MIR-21 may be a biomarker of inflammation [23041385]. | Human |
| SIRT6 | sirtuin 6 | SIRT6 is a critical modulator of cancer metabolism. SIRT6 is selectively downregulated in several cancers. Expression of SIRT6 predicts prognosis of tumor-free survival rates [23217706]. | Human |
| ELOVL2 | elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 | In breast, kidney and lung tissues the makers cg23606718 and cg16867657 were commonly differentially methylated with age and both have been annotated to ELOVL2 [23177740], which is linked to photoaging response in human skin [20514327]. | Human |
| GTPBP10 | GTP-binding protein 10 (putative) | Age-related differential methylation of the genetic marker rs42663, which is missense mutation in GTPBP10 is statistically significant association with age and aging rate. GTPB10 associates with cg27367526 in STEAP2 [23177740]. | Human |
| JAKMIP3 | Janus kinase and microtubule interacting protein 3 | Age-related differential methylation of the genetic marker rs2818384 which is synonymous to the mutation in JAKMIP3 is statistically significant association with age and aging rate. JAKMIP3 has a *cis* association with the aging differential methylated marker cg05652533 [23177740].
Copy-number variants of JAKMIP3 are associated with glioblastoma [Xiong et al. 2010].
Xiong, M., Dong, H., Siu, H., Peng, G., Wang, Y., and Jin, L. (2010). Genome-Wide Association Studies of Copy Number Variation in Glioblastoma. Proceedings of the 4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE), 1–4.
| Human |
| NEK4 | NIMA (never in mitosis gene a)-related kinase 4 | Age-related differential methylation of the genetic marker rs2230534 which is synonymous to the mutation in NEK4 is statistically significant association with age and aging rate [23177740]. | Human |
| KLF14 | Kruppel-like factor 14 | Six aging differentially methylated markers lay within KLF14 [23177740]. | Human |
| SST | Somastatin | Two with age-related differential methylation markers lay within Somastatin (SST) [23177740] which declines with age and is linked to Alzheimer's disease [15778722]. | Human |
| MDB4 | methyl-CpG binding domain protein 4 | Methylation marker cg27193080 is significantly associated with age and its methylation fraction is influenced by the SNP variantrs140692. Both the SNP and the methylation marker map to the MBD4, with the SNP in an intron and the methylation marker just upstream of the coding region [23177740]. | Human |
