Circulatory Factors as Modulators of Brain Function and Aging BioScience Forum Circulatory Factors as Modulators of Brain Function and Aging

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When: Wednesday, May 24, 2017 6:00 PM - 9:00 PM

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The Holiday Inn
275 S Airport Blvd, South San Francisco, California 94080, USA

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Circulatory Factors as Modulators of Brain Function and Aging

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Brain aging leads to cognitive decline and is the main risk factor for sporadic forms of neurodegenerative diseases including Alzheimer’s disease. While brain cell and tissue intrinsic factors are likely key determinants of the aging process recent studies from our lab and others document a remarkable susceptibility of the brain to circulatory factors. Thus, blood borne factors from young mice or humans are sufficient to slow aspects of brain aging and improve cognitive function in old mice, and vice versa, factors from old mice are detrimental for young mice and impair cognition. We discovered tissue inhibitor of metalloproteases (TIMP)-2 to be sufficient and, in part, necessary to mediate the cognitive benefits of young human plasma on aged mouse brains. We are trying to understand the molecular basis of these observations and rejuvenation in general and explore their relevance for neurodegeneration and dementia.


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